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Aggregation of zinc‐free p53 is inhibited by Hsp90 but not other chaperones
The structured DNA‐binding domain (DBD) of p53 is a well‐known client protein of the chaperone Hsp90. The p53 DBD contains a single zinc ion, coordinated by the side chains of Cys176, His179, Cys238, and Cys242; zinc coordination plays a structural role to stabilize the DBD and is required for its D...
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| Publicado no: | Protein Sci |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons, Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6798128/ https://ncbi.nlm.nih.gov/pubmed/31503385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3726 |
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