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Stereoselective Synthesis of F-Ring Saturated Estrone-Derived Inhibitors of Hedgehog Signaling Based on Cyclopamine

[Image: see text] Previous work in this laboratory established that the readily available F-ring aromatic analog of cyclopamine is a highly potent inhibitor of Hedgehog signaling. The synthesis and biological evaluation of two F-ring saturated analogs that are more potent than the F-ring aromatic st...

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מידע ביבליוגרפי
Main Authors: Zhang, Zhihui, Baubet, Valérie, Ventocilla, Christian, Xiang, Chaomei, Dahmane, Nadia, Winkler, Jeffrey D.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3170508/
https://ncbi.nlm.nih.gov/pubmed/21842835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol2017966
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