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Studies Directed Toward the Elucidation of the Pharmacophore of Steroid-Based Sonic Hedgehog Signaling Inhibitors

[Image: see text] Previous work from our laboratory has established that the readily available steroid-based analog 2 of cyclopamine 1 is, like 1, a highly potent inhibitor of Hedgehog signaling. The first structure-activity relationship studies on 2, i.e., the synthesis and biological evaluation of...

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Bibliografiske detaljer
Main Authors: Isaacs, André K., Xiang, Chaomei, Baubet, Valérie, Dahmane, Nadia, Winkler, Jeffrey D.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184309/
https://ncbi.nlm.nih.gov/pubmed/21905689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol202020c
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