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Separation of mutational and transcriptional enhancers in immunoglobulin genes
Secondary immunoglobulin (Ig) gene diversification relies on activation-induced cytidine deaminase (AID) to create U:G mismatches that are subsequently fixed by mutagenic repair pathways. AID activity is focused to Ig loci by cis-regulatory DNA sequences named targeting elements. Here we show that i...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3169751/ https://ncbi.nlm.nih.gov/pubmed/21844395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1101568 |
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