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Separation of mutational and transcriptional enhancers in immunoglobulin genes

Secondary immunoglobulin (Ig) gene diversification relies on activation-induced cytidine deaminase (AID) to create U:G mismatches that are subsequently fixed by mutagenic repair pathways. AID activity is focused to Ig loci by cis-regulatory DNA sequences named targeting elements. Here we show that i...

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Detalhes bibliográficos
Main Authors: Kothapalli, Naga Rama, Collura, Kaitlin M., Norton, Darrell D., Fugmann, Sebastian D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169751/
https://ncbi.nlm.nih.gov/pubmed/21844395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1101568
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