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Immunoglobulin gene transcription ceases upon deletion of a distant enhancer.
The tissue-specific E mu enhancer within the immunoglobulin heavy chain (IgH) locus has recently been shown to be essential for efficient V region gene assembly in early B lineage cells. However, we and others have shown that late stage, Ig-secreting cells can produce IgH in the absence of E mu. In...
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| Publicado no: | EMBO J |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
1995
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394747/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8557042/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1995.tb00313.x |
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