Cell cycle– and cell growth–regulated proteolysis of mammalian CDC6 is dependent on APC–CDH1

CDC6 is conserved during evolution and is essential and limiting for the initiation of eukaryotic DNA replication. Human CDC6 activity is regulated by periodic transcription and CDK-regulated subcellular localization. Here, we show that, in addition to being absent from nonproliferating cells, CDC6...

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Bibliografiska uppgifter
Huvudupphovsmän: Petersen, Birgit Otzen, Wagener, Christian, Marinoni, Federica, Kramer, Edgar R., Melixetian, Marina, Denchi, Eros Lazzerini, Gieffers, Christian, Matteucci, Cristian, Peters, Jan-Michael, Helin, Kristian
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2000
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC316932/
https://ncbi.nlm.nih.gov/pubmed/10995389
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