Cell cycle– and cell growth–regulated proteolysis of mammalian CDC6 is dependent on APC–CDH1

CDC6 is conserved during evolution and is essential and limiting for the initiation of eukaryotic DNA replication. Human CDC6 activity is regulated by periodic transcription and CDK-regulated subcellular localization. Here, we show that, in addition to being absent from nonproliferating cells, CDC6...

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Detalhes bibliográficos
Main Authors: Petersen, Birgit Otzen, Wagener, Christian, Marinoni, Federica, Kramer, Edgar R., Melixetian, Marina, Denchi, Eros Lazzerini, Gieffers, Christian, Matteucci, Cristian, Peters, Jan-Michael, Helin, Kristian
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2000
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC316932/
https://ncbi.nlm.nih.gov/pubmed/10995389
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