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Uncoupling of the hnRNP Npl3p from mRNAs during the stress-induced block in mRNA export

Npl3p, the major mRNA-binding protein of the yeast Saccharomyces cerevisiae shuttles between the nucleus and the cytoplasm. A single amino acid change in the carboxyl terminus of Npl3p (E409 → K) renders the mutant protein largely cytoplasmic because of a delay in its import into the nucleus. This i...

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Publicat a:Genes Dev
Autors principals: Krebber, Heike, Taura, Tetsuya, Lee, Margaret S., Silver, Pamela A.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 1999
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316916/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10444597/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.15.1994
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