Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells

Notch1 regulates gene expression by associating with the DNA-binding factor RBPJ and is oncogenic in murine and human T-cell progenitors. Using ChIP-Seq, we find that in human and murine T-lymphoblastic leukemia (TLL) genomes Notch1 binds preferentially to promoters, to RBPJ binding sites, and near...

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Main Authors: Wang, Hongfang, Zou, James, Zhao, Bo, Johannsen, Eric, Ashworth, Todd, Wong, Hoifung, Pear, Warren S., Schug, Jonathan, Blacklow, Stephen C., Arnett, Kelly L., Bernstein, Bradley E., Kieff, Elliott, Aster, Jon C.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2011
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169118/
https://ncbi.nlm.nih.gov/pubmed/21737748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109023108
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