NOTCH1–RBPJ complexes drive target gene expression through dynamic interactions with superenhancers

The main oncogenic driver in T-lymphoblastic leukemia is NOTCH1, which activates genes by forming chromatin-associated Notch transcription complexes. Gamma-secretase-inhibitor treatment prevents NOTCH1 nuclear localization, but most genes with NOTCH1-binding sites are insensitive to gamma-secretase...

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Autori principali: Wang, Hongfang, Zang, Chongzhi, Taing, Len, Arnett, Kelly L., Wong, Yinling Joey, Pear, Warren S., Blacklow, Stephen C., Liu, X. Shirley, Aster, Jon C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896193/
https://ncbi.nlm.nih.gov/pubmed/24374627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1315023111
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