טוען...
NOTCH1–RBPJ complexes drive target gene expression through dynamic interactions with superenhancers
The main oncogenic driver in T-lymphoblastic leukemia is NOTCH1, which activates genes by forming chromatin-associated Notch transcription complexes. Gamma-secretase-inhibitor treatment prevents NOTCH1 nuclear localization, but most genes with NOTCH1-binding sites are insensitive to gamma-secretase...
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| Main Authors: | , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
National Academy of Sciences
2014
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3896193/ https://ncbi.nlm.nih.gov/pubmed/24374627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1315023111 |
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