Role of TRAIL and the pro-apoptotic Bcl-2 homolog Bim in acetaminophen-induced liver damage

Acetaminophen (N-acetyl-para-aminophenol (APAP), paracetamol) is a commonly used analgesic and antipyretic agent. Although considered safe at therapeutic doses, accidental or intentional overdose causes acute liver failure characterized by centrilobular hepatic necrosis with high morbidity and morta...

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Bibliografiske detaljer
Main Authors: Badmann, A, Keough, A, Kaufmann, T, Bouillet, P, Brunner, T, Corazza, N
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3168997/
https://ncbi.nlm.nih.gov/pubmed/21654829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2011.55
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