Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span
SHIP is a 145-kD SH2-containing inositol-5-phosphatase widely expressed in hemopoietic cells. It was first identified as a tyrosine phosphoprotein associated with Shc in response to numerous cytokines. SHIP has been implicated in FcγRIIB receptor-mediated negative signaling in B cells and mast cells...
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| Опубліковано в:: | Genes Dev |
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| Автори: | , , , , , , , , , |
| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Cold Spring Harbor Laboratory Press
1998
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| Предмети: | |
| Онлайн доступ: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316868/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9620849/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.11.1610 |
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