Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

SHIP is a 145-kD SH2-containing inositol-5-phosphatase widely expressed in hemopoietic cells. It was first identified as a tyrosine phosphoprotein associated with Shc in response to numerous cytokines. SHIP has been implicated in FcγRIIB receptor-mediated negative signaling in B cells and mast cells...

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Main Authors: Helgason, Cheryl D., Damen, Jacqueline E., Rosten, Patty, Grewal, Rewa, Sorensen, Poul, Chappel, Suzanne M., Borowski, Anita, Jirik, Frank, Krystal, Gerald, Humphries, R. Keith
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 1998
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC316868/
https://ncbi.nlm.nih.gov/pubmed/9620849
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