Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

SHIP is a 145-kD SH2-containing inositol-5-phosphatase widely expressed in hemopoietic cells. It was first identified as a tyrosine phosphoprotein associated with Shc in response to numerous cytokines. SHIP has been implicated in FcγRIIB receptor-mediated negative signaling in B cells and mast cells...

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Pubblicato in:	Genes Dev
Autori principali:	Helgason, Cheryl D., Damen, Jacqueline E., Rosten, Patty, Grewal, Rewa, Sorensen, Poul, Chappel, Suzanne M., Borowski, Anita, Jirik, Frank, Krystal, Gerald, Humphries, R. Keith
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Cold Spring Harbor Laboratory Press 1998
Soggetti:	Research Paper
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316868/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9620849/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.12.11.1610
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