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Complete lack of NF-κB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation

NF-κB activity is induced by cytokines, stress, and pathogens. IKK1 and IKK2 are critical IκB kinases in NF-κB activation. In this study mice lacking IKK1 and IKK2 died at E12. Additional defect in neurulation associated with enhanced apoptosis in the neuroepithelium was also observed. MEF cells fro...

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Detaylı Bibliyografya
Yayımlandı:Genes Dev
Asıl Yazarlar: Li, Qiutang, Estepa, Gabriela, Memet, Sylvie, Israel, Alain, Verma, Inder M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 2000
Konular:
Online Erişim:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316792/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10898787/
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