Severe liver degeneration and lack of NF-κB activation in NEMO/IKKγ-deficient mice

Phosphorylation of IκB, an inhibitor of NF-κB, is an important step in the activation of the transcription factor NF-κB. Phosphorylation is mediated by the IκB kinase (IKK) complex, known to contain two catalytic subunits: IKKα and IKKβ. A novel, noncatalytic component of this kinase complex called...

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Autores principales: Rudolph, Dorothea, Yeh, Wen-Chen, Wakeham, Andrew, Rudolph, Bettina, Nallainathan, Dhani, Potter, Julia, Elia, Andrew J., Mak, Tak W.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2000
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Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC316493/
https://ncbi.nlm.nih.gov/pubmed/10766741
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