Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation.

Nuclear factor κB (NF-κB) is a transcription factor important for regulating innate and adaptive immunity, cellular proliferation, apoptosis, and senescence. Dysregulation of NF-κB and its upstream regulator IκB kinase (IKK) contributes to the pathogenesis of multiple inflammatory and degenerative d...

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Hlavní autoři:	Jing Zhao, Lei Zhang, Xiaodong Mu, Christelle Doebelin, William Nguyen, Callen Wallace, Daniel P Reay, Sara J McGowan, Lana Corbo, Paula R Clemens, Gabriela Mustata Wilson, Simon C Watkins, Laura A Solt, Michael D Cameron, Johnny Huard, Laura J Niedernhofer, Theodore M Kamenecka, Paul D Robbins
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2018-06-01
Edice:	PLoS Biology
On-line přístup:	https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pbio.2004663/2/pbio.2004663.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210218%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210218T122026Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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