IκBα/IκBε deficiency reveals that a critical NF-κB dosage is required for lymphocyte survival

In most cells, the NF-κB transcription factor is sequestered in the cytoplasm by interaction with inhibitory proteins, the IκBs. Here, we show that combined IκBα/IκBε deficiency in mice leads to neonatal death, elevated κB binding activity, overexpression of NF-κB target genes, and disruption of lym...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Goudeau, Bertrand, Huetz, François, Samson, Sandrine, Di Santo, James P., Cumano, Ana, Beg, Amer, Israël, Alain, Mémet, Sylvie
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2003
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307648/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14665694/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2535880100
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