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IκBα/IκBε deficiency reveals that a critical NF-κB dosage is required for lymphocyte survival
In most cells, the NF-κB transcription factor is sequestered in the cytoplasm by interaction with inhibitory proteins, the IκBs. Here, we show that combined IκBα/IκBε deficiency in mice leads to neonatal death, elevated κB binding activity, overexpression of NF-κB target genes, and disruption of lym...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2003
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC307648/ https://ncbi.nlm.nih.gov/pubmed/14665694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2535880100 |
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