Učitavanje...
IκBα/IκBε deficiency reveals that a critical NF-κB dosage is required for lymphocyte survival
In most cells, the NF-κB transcription factor is sequestered in the cytoplasm by interaction with inhibitory proteins, the IκBs. Here, we show that combined IκBα/IκBε deficiency in mice leads to neonatal death, elevated κB binding activity, overexpression of NF-κB target genes, and disruption of lym...
Spremljeno u:
| Izdano u: | Proc Natl Acad Sci U S A |
|---|---|
| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2003
|
| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307648/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14665694/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2535880100 |
| Oznake: |
Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!
|