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RhoA and RhoC have distinct roles in migration and invasion by acting through different targets

Several studies suggest that RhoA and RhoC, despite their sequence similarity, have different roles in cell migration and invasion, but the molecular basis for this is not known. Using RNAi, we show that RhoA-depleted cells became elongated and extended multiple Rac1-driven narrow protrusions in 2D...

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Detalhes bibliográficos
Main Authors: Vega, Francisco M., Fruhwirth, Gilbert, Ng, Tony, Ridley, Anne J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166870/
https://ncbi.nlm.nih.gov/pubmed/21576392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201011038
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