Hedgehog Signaling Antagonist Promotes Regression of Both Liver Fibrosis and Hepatocellular Carcinoma in a Murine Model of Primary Liver Cancer

OBJECTIVE: Chronic fibrosing liver injury is a major risk factor for hepatocarcinogenesis in humans. Mice with targeted deletion of Mdr2 (the murine ortholog of MDR3) develop chronic fibrosing liver injury. Hepatocellular carcinoma (HCC) emerges spontaneously in such mice by 50–60 weeks of age, prov...

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Main Authors: Philips, George M., Chan, Isaac S., Swiderska, Marzena, Schroder, Vanessa T., Guy, Cynthia, Karaca, Gamze F., Moylan, Cynthia, Venkatraman, Talaignair, Feuerlein, Sebastian, Syn, Wing-Kin, Jung, Youngmi, Witek, Rafal P., Choi, Steve, Michelotti, Gregory A., Rangwala, Fatima, Merkle, Elmar, Lascola, Christopher, Diehl, Anna Mae
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2011
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166282/
https://ncbi.nlm.nih.gov/pubmed/21912653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023943
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