Hedgehog Signaling Antagonist Promotes Regression of Both Liver Fibrosis and Hepatocellular Carcinoma in a Murine Model of Primary Liver Cancer

OBJECTIVE: Chronic fibrosing liver injury is a major risk factor for hepatocarcinogenesis in humans. Mice with targeted deletion of Mdr2 (the murine ortholog of MDR3) develop chronic fibrosing liver injury. Hepatocellular carcinoma (HCC) emerges spontaneously in such mice by 50–60 weeks of age, prov...

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Main Authors: Philips, George M., Chan, Isaac S., Swiderska, Marzena, Schroder, Vanessa T., Guy, Cynthia, Karaca, Gamze F., Moylan, Cynthia, Venkatraman, Talaignair, Feuerlein, Sebastian, Syn, Wing-Kin, Jung, Youngmi, Witek, Rafal P., Choi, Steve, Michelotti, Gregory A., Rangwala, Fatima, Merkle, Elmar, Lascola, Christopher, Diehl, Anna Mae
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166282/
https://ncbi.nlm.nih.gov/pubmed/21912653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023943
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