Leptin Promotes the Myofibroblastic Phenotype in Hepatic Stellate Cells by Activating the Hedgehog Pathway

Trans-differentiation of quiescent hepatic stellate cells (Q-HSCs), which exhibit epithelial and adipocytic features, into myofibroblastic-HSC (MF-HSCs) is a key event in liver fibrosis. Culture models demonstrated that Hedgehog (Hh) pathway activation is required for transition of epithelioid/adipo...

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Detalhes bibliográficos
Principais autores: Choi, Steve S., Syn, Wing-Kin, Karaca, Gamze F., Omenetti, Alessia, Moylan, Cynthia A., Witek, Rafal P., Agboola, Kolade M., Jung, Youngmi, Michelotti, Gregory A., Diehl, Anna Mae
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978583/
https://ncbi.nlm.nih.gov/pubmed/20843817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.168542
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