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The 8-Aminoquinoline Analogue Sitamaquine Causes Oxidative Stress in Leishmania donovani Promastigotes by Targeting Succinate Dehydrogenase

The 8-aminoquinoline analogue sitamaquine (SQ) is an oral antileishmanial drug currently undergoing phase 2b clinical trials for the treatment of visceral leishmaniasis. In the present study, we investigated the mechanism of action of this drug in Leishmania donovani promastigotes. SQ causes a dose-...

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Bibliografiske detaljer
Main Authors: Carvalho, Luis, Luque-Ortega, Juan Román, López-Martín, Carmen, Castanys, Santiago, Rivas, Luis, Gamarro, Francisco
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3165367/
https://ncbi.nlm.nih.gov/pubmed/21670183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00520-11
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