Polycystin-1 Is Required for Stereocilia Structure But Not for Mechanotransduction in Inner Ear Hair Cells

The polycystic kidney disease-1 (Pkd1) gene encodes a large transmembrane protein (polycystin-1, or PC-1) that is reported to function as a fluid flow sensor in the kidney. As a member of the transient receptor potential family, PC-1 has also been hypothesized to play a role in the elusive mechanoel...

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Bibliographic Details
Main Authors: Steigelman, Katherine A., Lelli, Andrea, Wu, Xudong, Gao, Jiangang, Lin, Susan, Piontek, Klaus, Wodarczyk, Claas, Boletta, Alessandra, Kim, Hyunho, Qian, Feng, Germino, Gregory, Géléoc, Gwenaëlle S. G., Holt, Jeffrey R., Zuo, Jian
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164988/
https://ncbi.nlm.nih.gov/pubmed/21865467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6531-10.2011
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