Polycystin-1 Is Required for Stereocilia Structure But Not for Mechanotransduction in Inner Ear Hair Cells

The polycystic kidney disease-1 (Pkd1) gene encodes a large transmembrane protein (polycystin-1, or PC-1) that is reported to function as a fluid flow sensor in the kidney. As a member of the transient receptor potential family, PC-1 has also been hypothesized to play a role in the elusive mechanoel...

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Bibliografiska uppgifter
Huvudupphovsmän: Steigelman, Katherine A., Lelli, Andrea, Wu, Xudong, Gao, Jiangang, Lin, Susan, Piontek, Klaus, Wodarczyk, Claas, Boletta, Alessandra, Kim, Hyunho, Qian, Feng, Germino, Gregory, Géléoc, Gwenaëlle S. G., Holt, Jeffrey R., Zuo, Jian
Materialtyp: Artigo
Språk:Inglês
Publicerad: Society for Neuroscience 2011
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164988/
https://ncbi.nlm.nih.gov/pubmed/21865467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6531-10.2011
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