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Polycystin-1 Is Required for Stereocilia Structure But Not for Mechanotransduction in Inner Ear Hair Cells

The polycystic kidney disease-1 (Pkd1) gene encodes a large transmembrane protein (polycystin-1, or PC-1) that is reported to function as a fluid flow sensor in the kidney. As a member of the transient receptor potential family, PC-1 has also been hypothesized to play a role in the elusive mechanoel...

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Detalles Bibliográficos
Autores principales: Steigelman, Katherine A., Lelli, Andrea, Wu, Xudong, Gao, Jiangang, Lin, Susan, Piontek, Klaus, Wodarczyk, Claas, Boletta, Alessandra, Kim, Hyunho, Qian, Feng, Germino, Gregory, Géléoc, Gwenaëlle S. G., Holt, Jeffrey R., Zuo, Jian
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164988/
https://ncbi.nlm.nih.gov/pubmed/21865467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6531-10.2011
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