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Synthesis and in Vitro Evaluation of New Analogues as Inhibitors for Phosphodiesterase 10A
A series of analogues were synthesized by optimizing the structure of papaverine. The in vitro PDE10A binding affinity ( IC(50)) values for these new analogues were measured; for compounds that have IC(50) value less than 60 nM for PDE10A, the binding affinities (IC(50) value) for PDE3A and PDE3B we...
में बचाया:
| मुख्य लेखकों: | , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2011
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3164901/ https://ncbi.nlm.nih.gov/pubmed/21705115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2011.05.072 |
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