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Synthesis and in vitro characterization of cinnoline and benzimidazole analogues as phosphodiesterase 10A inhibitors

Fifteen cinnoline analogues and six benzimidazole phosphodiesterase 10A (PDE10A) inhibitors were synthesized as potential PET radiopharmaceuticals and their in vitro activity as PDE10A inhibitors was determined. Nine out of twenty-one compounds were potent inhibitors of PDE10A with IC(50) values ran...

詳細記述

保存先:
書誌詳細
出版年:Bioorg Med Chem Lett
主要な著者: Yang, Hao, Murigi, Francis N., Wang, Zhijian, Li, Junfeng, Jin, Hongjun, Tu, Zhude
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321733/
https://ncbi.nlm.nih.gov/pubmed/25592707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.12.054
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