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Torsional Steering Controls the Stereoselectivity of Epoxidation in the Guanacastepene A Synthesis

[Image: see text] The stereoselectivity of the key epoxidation step in the synthesis of Guanacastepene A is shown to be controlled by torsional steering. In this particular epoxidation reaction, the transition structure energetic difference is enhanced by the great asynchronicity of the forming C-O...

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Detalhes bibliográficos
Main Authors: Cheong, Paul Ha-Yeon, Yun, Heedong, Danishefsky, Samuel J., Houk, K. N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164362/
https://ncbi.nlm.nih.gov/pubmed/16597098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol052862g
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