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NF-κB and BRG1 bind a distal regulatory element in the IL-3/GM-CSF locus
We investigated gene regulation at the IL-3/GM-CSF gene cluster. We found BRG1, a SWI/SNF remodeling ATPase, bound a distal element, CNSa. BRG1 binding was strongest in differentiated, stimulated T helper cells, paralleling IL-3 and GM-CSF expression. Depletion of BRG1 reduced IL-3 and GM-CSF transc...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3163777/ https://ncbi.nlm.nih.gov/pubmed/21831442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2011.07.016 |
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