IL-1R signaling promotes STAT3 and NF-κB factor recruitment to distal cis-regulatory elements that regulate Il17a/f transcription

Interleukin (IL)-1β plays a critical role in IL-6β– and transforming growth factor β (TGFβ)–initiated Th17 differentiation and induction of Th17-mediated autoimmunity. However, the means by which IL-1 regulates various aspects of Th17 development remain poorly understood. We recently reported that I...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Whitley, Sarah K., Balasubramani, Anand, Zindl, Carlene L., Sen, Ranjan, Shibata, Yoichiro, Crawford, Gregory E., Weathington, Nathaniel M., Hatton, Robin D., Weaver, Casey T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187645/
https://ncbi.nlm.nih.gov/pubmed/30093408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002721
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