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IL-1 signaling modulates STAT activation to antagonize retinoic acid signaling and control Th17–iTreg balance
Interleukin 17 (IL-17)-producing helper (T(H)17) and inducible regulatory CD4(+) T (iT(reg)) cells emerge from an overlapping developmental program. In the intestines, the vitamin A metabolite retinoic acid (RA) is produced at steady state and acts as an important cofactor to induce iT(reg) cell dev...
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| Pubblicato in: | Nat Immunol |
|---|---|
| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4790724/ https://ncbi.nlm.nih.gov/pubmed/25642823 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3099 |
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