IL-1 signaling modulates STAT activation to antagonize retinoic acid signaling and control Th17–iTreg balance

Interleukin 17 (IL-17)-producing helper (T(H)17) and inducible regulatory CD4(+) T (iT(reg)) cells emerge from an overlapping developmental program. In the intestines, the vitamin A metabolite retinoic acid (RA) is produced at steady state and acts as an important cofactor to induce iT(reg) cell dev...

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Publié dans:Nat Immunol
Auteurs principaux: Basu, Rajatava, Whitley, Sarah K., Bhaumik, Suniti, Zindl, Carlene L., Schoeb, Trenton R., Benveniste, Etty N., Pear, Warren S., Hatton, Robin D., Weaver, Casey T.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4790724/
https://ncbi.nlm.nih.gov/pubmed/25642823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3099
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