Deletion of a Conserved cis-Element in the Ifng Locus Highlights the Role of Acute Histone Acetylation in Modulating Inducible Gene Transcription

Differentiation-dependent regulation of the Ifng cytokine gene locus in T helper (Th) cells has emerged as an excellent model for functional study of distal elements that control lineage-specific gene expression. We previously identified a cis-regulatory element located 22 kb upstream of the Ifng ge...

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Main Authors: Balasubramani, Anand, Winstead, Colleen J., Turner, Henrietta, Janowski, Karen M., Harbour, Stacey N., Shibata, Yoichiro, Crawford, Gregory E., Hatton, Robin D., Weaver, Casey T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3886902/
https://ncbi.nlm.nih.gov/pubmed/24415943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003969
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