Epigenetic Instability of Cytokine and Transcription Factor Gene Loci Underlies Plasticity of the T helper 17 Cell Lineage

Phenotypic plasticity of T helper 17 (Th17) cells suggests instability of chromatin structure of key genes of this lineage. Here we identify epigenetic modifications across the clustered Il17a and Il17f, and Ifng loci before and after differential IL-12 or TGFβ signaling, which induce divergent fate...

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Detalhes bibliográficos
Main Authors: Mukasa, Ryuta, Balasubramani, Anand, Lee, Yun Kyung, Whitley, Sarah K., Weaver, Benjamin T., Shibata, Yoichiro, Crawford, Gregory E., Hatton, Robin D., Weaver, Casey T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129685/
https://ncbi.nlm.nih.gov/pubmed/20471290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.04.016
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