Epigenetic Instability of Cytokine and Transcription Factor Gene Loci Underlies Plasticity of the T helper 17 Cell Lineage

Phenotypic plasticity of T helper 17 (Th17) cells suggests instability of chromatin structure of key genes of this lineage. Here we identify epigenetic modifications across the clustered Il17a and Il17f, and Ifng loci before and after differential IL-12 or TGFβ signaling, which induce divergent fate...

Full description

Saved in:
Bibliographic Details
Main Authors: Mukasa, Ryuta, Balasubramani, Anand, Lee, Yun Kyung, Whitley, Sarah K., Weaver, Benjamin T., Shibata, Yoichiro, Crawford, Gregory E., Hatton, Robin D., Weaver, Casey T.
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129685/
https://ncbi.nlm.nih.gov/pubmed/20471290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.04.016
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items