Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Transcription factor Nrf2 is essential for the antioxidant responsive element (ARE)-mediated induction of phase II detoxifying and oxidative stress enzyme genes. Detailed analysis of differential Nrf2 activity displayed in transfected cell lines ultimately led to the identification of a new protein,...

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Autores principales: Itoh, Ken, Wakabayashi, Nobunao, Katoh, Yasutake, Ishii, Tetsuro, Igarashi, Kazuhiko, Engel, James Douglas, Yamamoto, Masayuki
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 1999
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC316370/
https://ncbi.nlm.nih.gov/pubmed/9887101
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