Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

Transcription factor Nrf2 regulates basal and inducible expression of phase 2 proteins that protect animal cells against the toxic effects of electrophiles and oxidants. Under basal conditions, Nrf2 is sequestered in the cytoplasm by Keap1, a multidomain, cysteinerich protein that is bound to the ac...

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Bibliographic Details
Main Authors: Kang, Moon-Il, Kobayashi, Akira, Wakabayashi, Nobunao, Kim, Sang-Geon, Yamamoto, Masayuki
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC357049/
https://ncbi.nlm.nih.gov/pubmed/14764898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308347100
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