Additional Acetylcholine (ACh) Binding Site at α4/α4 Interface of (α4β2)(2)α4 Nicotinic Receptor Influences Agonist Sensitivity

Nicotinic acetylcholine receptor (nAChR) α4 and β2 subunits assemble in two alternate stoichiometries to produce (α4β2)(2)α4 and (α4β2)(2)β2, which display different agonist sensitivities. Functionally relevant agonist binding sites are thought to be located at α4(+)/β2(−) subunit interfaces, but be...

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Detalhes bibliográficos
Main Authors: Mazzaferro, Simone, Benallegue, Naïl, Carbone, Anna, Gasparri, Federica, Vijayan, Ranjit, Biggin, Philip C., Moroni, Mirko, Bermudez, Isabel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162463/
https://ncbi.nlm.nih.gov/pubmed/21757735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.262014
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