Non-equivalent Ligand Selectivity of Agonist Sites in (α4β2)(2)α4 Nicotinic Acetylcholine Receptors: A KEY DETERMINANT OF AGONIST EFFICACY

The α4β2 nicotinic acetylcholine receptor (nAChR) is the most abundant nAChR type in the brain, and this receptor type exists in alternate (α4β2)(2)α4 and (α4β2)(2)β2 forms, which are activated by agonists with strikingly differing efficacies. Recent breakthroughs have identified an additional opera...

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Detalhes bibliográficos
Main Authors: Mazzaferro, Simone, Gasparri, Federica, New, Karina, Alcaino, Constanza, Faundez, Manuel, Iturriaga Vasquez, Patricio, Vijayan, Ranjit, Biggin, Philip C., Bermudez, Isabel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4118137/
https://ncbi.nlm.nih.gov/pubmed/24936069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.555136
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