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The additional ACh binding site at the α4(+)/α4(−) interface of the (α4β2)(2)α4 nicotinic ACh receptor contributes to desensitization

BACKGROUND AND PURPOSE: Nicotinic ACh (α4β2)(2)α4 receptors are highly prone to desensitization by prolonged exposure to low concentrations of agonist. Here, we report on the sensitivity of the three agonist sites of the (α4β2)(2)α4 to desensitization induced by prolonged exposure to ACh. We present...

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Bibliografiske detaljer
Main Authors: Benallegue, N, Mazzaferro, S, Alcaino, C, Bermudez, I
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834755/
https://ncbi.nlm.nih.gov/pubmed/23742319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12268
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