Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase

Human thymidylate synthase is a homodimeric enzyme that plays a key role in DNA synthesis and is a target for several clinically important anticancer drugs that bind to its active site. We have designed peptides to specifically target its dimer interface. Here we show through X-ray diffraction, spec...

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Autors principals: Cardinale, Daniela, Guaitoli, Giambattista, Tondi, Donatella, Luciani, Rosaria, Henrich, Stefan, Salo-Ahen, Outi M. H., Ferrari, Stefania, Marverti, Gaetano, Guerrieri, Davide, Ligabue, Alessio, Frassineti, Chiara, Pozzi, Cecilia, Mangani, Stefano, Fessas, Dimitrios, Guerrini, Remo, Ponterini, Glauco, Wade, Rebecca C., Costi, M. Paola
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3161595/
https://ncbi.nlm.nih.gov/pubmed/21795601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104829108
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