Translational repression of thymidylate synthase by targeting its mRNA

Resistance to drugs targeting human thymidylate synthase (TS) poses a major challenge in the field of anti-cancer therapeutics. Overexpression of the TS protein has been implicated as one of the factors leading to the development of resistance. Therefore, repressing translation by targeting the TS m...

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Main Authors: Garg, Divita, Beribisky, Alexander V., Ponterini, Glauco, Ligabue, Alessio, Marverti, Gaetano, Martello, Andrea, Costi, M. Paola, Sattler, Michael, Wade, Rebecca C.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2013
主題:
Molecular Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627590/
https://ncbi.nlm.nih.gov/pubmed/23423353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt098
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