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Transcriptional Activation and Cell Cycle Block Are the Keys for 5-Fluorouracil Induced Up-Regulation of Human Thymidylate Synthase Expression

BACKGROUND: 5-fluorouracil, a commonly used chemotherapeutic agent, up-regulates expression of human thymidylate synthase (hTS). Several different regulatory mechanisms have been proposed to mediate this up-regulation in distinct cell lines, but their specific contributions in a single cell line hav...

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Detalhes bibliográficos
Main Authors: Ligabue, Alessio, Marverti, Gaetano, Liebl, Ursula, Myllykallio, Hannu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467224/
https://ncbi.nlm.nih.gov/pubmed/23056627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047318
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