Hotspots in an Obligate Homodimeric Anticancer Target. Structural and Functional Effects of Interfacial Mutations in Human Thymidylate Synthase

Human thymidylate synthase (hTS), a target for antiproliferative drugs, is an obligate homodimer. Single-point mutations to alanine at the monomer–monomer interface may enable the identification of specific residues that delineate sites for drugs aimed at perturbing the protein–protein interactions...

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Опубликовано в: :J Med Chem
Главные авторы: Salo-Ahen, Outi M. H., Tochowicz, Anna, Pozzi, Cecilia, Cardinale, Daniela, Ferrari, Stefania, Boum, Yap, Mangani, Stefano, Stroud, Robert M., Saxena, Puneet, Myllykallio, Hannu, Costi, Maria Paola, Ponterini, Glauco, Wade, Rebecca C.
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4634673/
https://ncbi.nlm.nih.gov/pubmed/25798950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00137
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