Evidence of Destabilization of the Human Thymidylate Synthase (hTS) Dimeric Structure Induced by the Interface Mutation Q62R

In human cells, thymidylate synthase (TS) provides the only source of 2′-deoxythymidyne-5′-monophosphate (dTMP), which is required for DNA biosynthesis. Because of its pivotal role, human TS (hTS) represents a validated target for anticancer chemotherapy. Nonetheless, the efficacy of drugs blocking...

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Bibliographic Details
Published in:Biomolecules
Main Authors: Pozzi, Cecilia, Lopresti, Ludovica, Santucci, Matteo, Costi, Maria Paola, Mangani, Stefano
Format: Artigo
Language:Inglês
Published: MDPI 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6523895/
https://ncbi.nlm.nih.gov/pubmed/30987202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9040134
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