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Native state interconversion of a metamorphic protein requires global unfolding

Lymphotactin (Ltn) is a unique chemokine that under physiological solution conditions displays large-scale structural heterogeneity, defining a new category of ‘metamorphic proteins’. Previous Ltn studies have indicated that each form is required for proper function, but the mechanism of interconver...

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Hlavní autoři: Tyler, Robert C., Murray, Nathan J., Peterson, Francis C., Volkman, Brian F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160782/
https://ncbi.nlm.nih.gov/pubmed/21776971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200750k
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