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Evolution of Fold-Switching in a Metamorphic Protein
Metamorphic proteins switch between different folds, defying the protein folding paradigm. It is unclear how fold-switching arises during evolution. Using ancestral reconstruction and NMR, we studied the evolution of the metamorphic protein XCL1, which has two distinct folds with different functions...
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| Опубликовано в: : | Science |
|---|---|
| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2021
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8017559/ https://ncbi.nlm.nih.gov/pubmed/33384377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abd8700 |
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