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Engineering the metamorphic chemokine Lymphotactin/XCL1 into the GAG-binding, HIV-inhibitory dimer conformation
Unlike other chemokines, XCL1 undergoes a distinct metamorphic interconversion between a canonical monomeric chemokine fold and a unique β-sandwich dimer. The monomeric conformation binds and activates the receptor XCR1, while the dimer binds extracellular matrix glycosaminoglycans and has been asso...
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| Publicado no: | ACS Chem Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5028202/ https://ncbi.nlm.nih.gov/pubmed/26302421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00542 |
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