Engineering the metamorphic chemokine Lymphotactin/XCL1 into the GAG-binding, HIV-inhibitory dimer conformation

Unlike other chemokines, XCL1 undergoes a distinct metamorphic interconversion between a canonical monomeric chemokine fold and a unique β-sandwich dimer. The monomeric conformation binds and activates the receptor XCR1, while the dimer binds extracellular matrix glycosaminoglycans and has been asso...

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Xehetasun bibliografikoak
Argitaratua izan da:ACS Chem Biol
Egile Nagusiak: Fox, Jamie C., Tyler, Robert C., Guzzo, Christina, Tuinstra, Robbyn L., Peterson, Francis C., Lusso, Paolo, Volkman, Brian F.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5028202/
https://ncbi.nlm.nih.gov/pubmed/26302421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00542
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