The CD8-derived chemokine XCL1/lymphotactin is a conformation-dependent, broad-spectrum inhibitor of HIV-1.

CD8+ T cells play a key role in the in vivo control of HIV-1 replication via their cytolytic activity as well as their ability to secrete non-lytic soluble suppressive factors. Although the chemokines that naturally bind CCR5 (CCL3/MIP-1α, CCL4/MIP- 1β, CCL5/RANTES) are major components of the CD8-d...

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Hlavní autoři: Christina Guzzo, Jamie Fox, Yin Lin, Huiyi Miao, Raffaello Cimbro, Brian F Volkman, Anthony S Fauci, Paolo Lusso
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science (PLoS) 2013-01-01
Edice:PLoS Pathogens
On-line přístup:http://europepmc.org/articles/PMC3873461?pdf=render
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