Autoregulation of Parkin activity through its ubiquitin-like domain

Parkin is an E3-ubiquitin ligase belonging to the RBR (RING–InBetweenRING–RING family), and is involved in the neurodegenerative disorder Parkinson's disease. Autosomal recessive juvenile Parkinsonism, which is one of the most common familial forms of the disease, is directly linked to mutation...

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Main Authors: Chaugule, Viduth K, Burchell, Lynn, Barber, Kathryn R, Sidhu, Ateesh, Leslie, Simon J, Shaw, Gary S, Walden, Helen
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3160258/
https://ncbi.nlm.nih.gov/pubmed/21694720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.204
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