Parkin-phosphoubiquitin complex reveals a cryptic ubiquitin binding site required for RBR ligase activity

RING-BETWEENRING-RING (RBR) E3 ligases are a class of ubiquitin ligases distinct from RING or HECT E3 ligases. An important RBR is Parkin, mutations in which lead to early onset hereditary Parkinsonism. Parkin and other RBRs share a catalytic RBR module, but are usually autoinhibited and activated v...

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Publicado no:Nat Struct Mol Biol
Main Authors: Kumar, Atul, Chaugule, Viduth K, Condos, Tara E C, Barber, Kathryn R, Johnson, Clare, Toth, Rachel, Sundaramoorthy, Ramasubramanian, Knebel, Axel, Shaw, Gary S, Walden, Helen
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5420311/
https://ncbi.nlm.nih.gov/pubmed/28414322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3400
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